Lab Head - Genomics


Basel Area - Allschwil, BL, CH



About Idorsia Pharmaceuticals Ltd

Idorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients.

In order to achieve this, we will develop Idorsia into one of Europe’s leading biopharmaceutical company, with a strong scientific core.

Headquartered in Switzerland - a European biotech hub - Idorsia is specialized in the discovery and development of small molecules, to transform the horizon of therapeutic options. Idorsia has a broad portfolio of innovative drugs in the pipeline, an experienced team, a fully-functional research center, and a strong balance sheet – the ideal constellation to bringing R&D efforts to business success.

Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 600 highly qualified specialists dedicated to realizing our ambitious targets.


Job Summary


We are looking for a motivated and experienced scientist that can champion the integration of genomics into our drug discovery and development projects. You will develop novel strategies to capitalize on the intrinsic value of (pharmaco) genomics and the overall translational biomarker strategy. You put great care in visualizing and explaining data to other functions, focussing on creating data for our projects. You’ll be able to bridge from computational and informatics disciplines to biology and pharmacology.  You will be responsible for applying the genomics expertise of the platform to a variety of projects in the fields of CV&Fibrosis, Immunology, Oncology and CNS.  Your major responsibility will lie in the integrated data analysis of complex datasets together with our data science team.  The genomics platform is part of the Translational Biomarker Group that currently plays an important role in the different discovery phases as well as in early clinical development. The Translational Biomarker Group believes that a pragmatic yet effective systems biology approach is key to our overall success.


Job Responsibilities


The Lab Head Genomics Platform will be responsible for:

  • Champion genomics in all its facets by active contributions to team and management meetings
  • Providing leadership to the existing genomics platform and its lab members
  • Active representation of the biomarker group, particularly the genomics capabilities in selected R&D teams 
  • Characterization of clinical translation through the animal model and clinical sample analyses
  • Driving the exploration of biomarkers and discovery of novel drug targets
  • Build the interface between the genomics platform and the data scientists in the Translational Biomarker group
  • Monitor and improve the effectiveness of Translational Biomarker strategy with other functions
  • Performing multivariate biomarker data analysis for a number of projects in close collaboration with functions in and outside the Translational Biomarker Group by putting experimental results into a biological context using internal and external knowledge databases
  • Maintaining and further developing capabilities for genomics data analysis with a focus on gene expression, exploring open-source solutions such as R/Bioconductor as well as commercial tools.
  • Improving the standardized workflows: data storage, data management, data retrieval with queries, data visualization and biological data interpretation based on the biological questions.
  • Presenting and discussing scientific results in international meetings, be a representative of the Biomarker strategy of Idorsia towards an international expert audience.
Candidate's Requirement
  • PhD in genetics, genomics or bioinformatics and minimally 5 years postdoctoral experience in the field of gene expression and/or NGS analysis proven by a strong publication record. Industry experience preferred 
  • Line management experience demonstrated by the supervision of associates minimally at the MSc level. 
  • Demonstrated lab experience. Experience with Illumina NextSeq and Nanostring nCounter and 10x Genomics Chromium would be of advantage
  • Demonstrated experience in the clinical implementation of genomics, e.g. diagnostics or clinical trials
  • Strong background in computational data analysis, use of R/Bioconductor and dissemination of  results by reports in markdown or shiny apps
  • Familiar working within a UNIX environment 
  • Further scripting and programming skills (e.g. Python/Perl/Java) would be of advantage
  • User experience with workflow management (such as Knime) would be of advantage
  • Proactive, forward-thinking and wish to be up-to-date with the technologies of this fast-evolving genomics field especially in NGS
  • Expert knowledge in genomics information resources and more advanced pathway / biological network and multivariate analyses 
  • Proficient in the English language (German and/or French would be an advantage)
  • Demonstrated experience of working in multicultural and multidisciplinary environments
  • Result oriented, problem solver
  • Dynamic team player with excellent communication and networking skills, flexible mindset and scientifically curious 
  • Experience in a pharmaceutical R&D environment and additional experience in genomics analysis would be an advantage
  • Experience in one or more of the therapeutic areas of interest to Idorsia would be an advantage


What Idorsia offers

  • Exciting opportunities for development and professional growth within our dynamic organization
  • A collaborative and solution-oriented environment where you can make a difference
  • An innovative and open culture in a truly multicultural environment
  • A competitive salary and generous social benefits


Work Location: Allschwil

Country: Switzerland

Business Area: Drug Discovery - Biology Translational Biomarkers

Schedule: Fulltime

Job Type: Permanent

Job ID: 1298


If you are interested, please click on apply now.

Please be informed that if you are selected for this position, your employment will be subject to a pre-employment background screening process, of which you would be informed in greater detail in due course.

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