Scientific Associate - Chemical Development


Basel Area - Allschwil, BL, CH


Job Responsibilities


•    Carrying out laboratory work ranging from route finding to multi-kilogram syntheses 
•    Optimizing reactions (1-100 g) by scrupulous control of reaction parameters using double-jacketed glass reactors 
•    Proposing alternative reaction conditions and synthesis pathways, and solve scale-up problems
•    Producing Active Pharmaceutical Ingredients (API) on kilogram scale (up to 30-liter reactors) to support preclinical development 
•    Monitoring reaction progress and performing compound analysis using TLC, LC-MS, GC/MS, NMR, or online techniques
•    Interpret analytical data and take appropriate action
•    Purify reaction products using standard techniques e.g. column chromatography, prep. HPLC, crystallization, or distillation 
•    Performing general lab duties and maintain a high standard of order and cleanliness 
•    Equipment champion of a dedicated technology or equipment
•    Plan practical work on a weekly basis, give timelines of own work
•    Accurate and regular documentation of experimental work using electronic lab journal 
•    Drafting of batch records for the non-GMP production of API’s and contributing to the risk assessment
•    Summarizing the weekly progress
•    Drafting of Mater Operation Records (MOR)
•    Ownership of parts of projects, like proposals of alternative routes for scale-up, or byproduct and impurity identification
•    Present at larger internal meetings (e.g. group meeting, CCB, PUM)


Candidate’s Requirements


•    BSc or MS diploma of a ‘Fachhochschule’ or ‘University of Applied Sciences’ in synthetic organic chemistry
•    3-5 years of experience in the field of organic synthesis 
•    Excellent skills in synthetic organic chemistry including asymmetric syntheses, reaction monitoring, work-up, analysis including online monitoring, and isolation techniques 
•    Experience within industrial Process R&D and scale-up is beneficial 
•    Experience in process safety (DSC, RC1, risk assessment) is beneficial
•    Routine use of modern methods to purify and characterize organic compounds (e.g. column chromatography, automated column chromatography, HPLC, LC-MS, NMR, GC, etc.)
•    Ability to plan and to independently and accurately document practical work
•    Hands-on attitude and problem-solving skills
•    Flexibility vis-à-vis changing work assignments 
•    Willingness to learn new skills and techniques
•    Good communication and team-working skills, role model
•    Fluent in English, both written and oral, and good knowledge of German 
•    Ability to meet stringent timelines, whilst not compromising the safety, and focusing on key goals
•    Safety first attitude
•    Evolved sense of profitability and cost consciousness
•    Service-oriented


What Idorsia offers


  • Exciting opportunities  for development and professional growth within our dynamic organization
  • A collaborative and solution-oriented environment where you can make a difference
  • An innovative and open culture in a truly multicultural environment
  • A competitive salary and generous social benefits


Work Location: Allschwil

Country: Switzerland

Business Unit: Chemistry - CD&CM

Schedule: Fulltime

Job Type: Permanent

Job ID: 1276

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