Scientist Modelling & Simulation - Nonclinical DMPK


Basel Area - Allschwil, BL, CH



About Idorsia Pharmaceuticals Ltd

Idorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients.

In order to achieve this, we will develop Idorsia into one of Europe’s leading biopharmaceutical company, with a strong scientific core.

Headquartered in Switzerland - a European biotech hub - Idorsia is specialized in the discovery and development of small molecules, to transform the horizon of therapeutic options. Idorsia has a broad portfolio of innovative drugs in the pipeline, an experienced team, a fully-functional research center, and a strong balance sheet – the ideal constellation to bringing R&D efforts to business success.

Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 600 highly qualified specialists dedicated to realizing our ambitious targets.



Job Responsibilities

  • Providing quantitative pharmacokinetic and pharmacodynamic modeling and simulation expertise to pre-clinical project and Life cycle teams
  • Applying quantitative PK/PD modeling and simulation to inform pre-clinical candidate selection
  • Being a champion and advocate for pharmacometrics within the company
  • Analyzing, interpreting and reporting pharmacokinetic and pharmacodynamic data from pre-clinical studies
  • Performing PK/PD simulations and predicting pre-clinical and clinical PK from nonclinical data as appropriate
  • Collaborating, mentoring and guiding other DMPK team members with pharmacometric support on their projects
  • Interacting cross-functionally with other departments including Medical Organization, Toxicology, Formulation and Discovery
  • Preparing and/or reviewing PK, PK/PD components of internal documents, briefing books and regulatory submission documents (e.g. IND, NDA, IB)
  • Actively preparing, reviewing and publishing scientific papers and abstracts
  • Representing the DMPK line on project teams spanning Discovery to NDA


Candidate’s Requirements

  • PhD in a relevant discipline (e.g. Quantitative Pharmacology, Pharmaceutical Sciences, Chemical Engineering)
  • 2 to 3 years experience in Modelling and Simulation in the Pharmaceutical Industry or Contract Research Organisations as a minimum
  • Proficient in spoken and written English
  • Strong understanding of pharmacokinetic and pharmacodynamic principles including PBPK
  • Good general knowledge about DMPK principles, DMPK in vitro assays, DMPK in vivo models
  • Hands-on experience with modeling and simulation software packages (WinNonlin Phoenix, Monolix, R)
  • Experience with Gastroplus, SimCYP would be advantageous
  • Must be a team player and great communicator
  • Self-driven and enthusiastic scientist


What Idorsia offers

  • Exciting opportunities  for development and professional growth within our dynamic organization
  • A collaborative and solution-oriented environment where you can make a difference
  • An innovative and open culture in a truly multicultural environment
  • A competitive salary and generous social benefits


Work  Location: Allschwil

Country: Switzerland

Business Area: Drug Discovery - Pharmacology DMPK

Schedule: Fulltime

Job Type: Permanent

Job ID: 1256


If you are interested, please click on apply now.

Please be informed that if you are selected for this position, your employment will be subject to a pre-employment background screening process, of which you would be informed in greater detail in due course.

Please note Idorsia operates a strictly-controlled list of preferred recruitment partners. For those partners who have no valid, signed Master Service Agreement in place with Idorsia all unsolicited resumes, CVs, anonymous profiles, or any other candidate details submitted through our website or to personal e-mail accounts of employees of Idorsia Pharmaceuticals (including any of its subsidiaries, affiliates or related companies) are considered the property of Idorsia Pharmaceuticals and are not subject to payment of any form of introduction, placement or referral fees.