Senior Scientific Associate

The purpose of Idorsia is to discover, develop, and commercialize innovative medicines to help more patients.

Headquartered in Switzerland – a biotech-hub of Europe – Idorsia is a high-potential biopharmaceutical company, specialized in the discovery, development and commercialization of innovative small molecules, with the aim of transforming the horizon of therapeutic options.

We are looking for a Senior Scientific Associate to join our Process Chemistry  R&D team !

Job Responsibilities

• Organic synthesis for route scouting, process development and production from gram to multi-kilogram scale
• Optimization of chemical reactions, including workup, product isolation and purification
• Maintenance of general scaleup equipment and individual responsibility for dedicated equipment or technology.
• Sourcing chemicals in bulk quantities from external suppliers, applying a cost-conscious mindset
• Assessment of reaction profiles and analysis of isolated compounds using TLC, LC/MS, GC/MS, NMR, or online techniques (e.g., reactIR) and drawing appropriate conclusions (e.g. proposing alternative reaction conditions and synthetic pathways based on observed side-products or impurities)
• Measurement and interpretation of advanced process safety data and corresponding adaptations to chemical processes.
• Planning of daily practical work in close exchange with the lab team and the responsible scientist.
• Accurate, detailed and reliable documentation of experimental work in electronic lab notebook (ELN) and project progress reports (PPR). Drafting of Master Operation Records (MOR) for scaleup campaigns.
• Presentation of research updates at internal group meetings. 

Candidate requirements

• MSc or equivalent degree in Chemistry
• Expert in preparative organic synthesis (ideally up to kg-scale)
• >5 years of industrial experience in process chemistry or a related field
• Experienced user of different reactor sizes and scaleup equipment (nutsche filters, charcoal filtration devices, thin-film distillations, gas scrubbers, etc.)
• Experienced in the handling of hazardous chemistry on scale (e.g. inert transfer of flammable solvents, handling of pyrophoric reagents, etc.)
• Experience in safe handling of highly valuable active pharmaceutical ingredients (API)
• Familiar with common process safety fundamentals and their assessment by techniques such as DSC and adiabatic calorimetry
• Experienced in the use of different isolation and purification techniques such as crystallization, distillation, automated column chromatography and preparative HPLC.
• Expert in analytical methods such as LC/MS, NMR, GC/MS, Karl-Fischer titration
• Ability to document all experimental work in an electronic lab notebook (ELN) in a clear, scientific way
• Ability to independently plan and execute practical work and a desire to solve complex, synthetic challenges.
• Well-organized with a hands-on attitude, keeping a positive mindset when faced by challenges under time pressure.
• Excellent communication- and team-working skills. Willingness to take over additional responsibilities
• Excellent command in spoken and written English
• Excellent computer skills 

Work  Location: Allschwil

Country: Switzerland

Business Area: Technical Operations - Product Development and Manufacturing - Chemsitry Process R&D

Schedule: Fulltime

Job Type: Permanent

Job ID: 4666

At Idorsia, we harness the power of difference, authenticity and inclusion to achieve business success. We are committed to fostering respect, fairness and equal opportunities for all job applicants and all our employees.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against based on disability.

Please be informed that if you are selected for this position, your employment will be subject to a pre-employment background screening process, of which you will be informed in greater detail in due course.

Idorsia operates a strictly controlled list of preferred recruitment partners. For those partners who have no valid, signed Master Service Agreement in place with Idorsia, please note that all unsolicited resumes, CVs, anonymous profiles, or any other candidate details submitted through our website or to personal e-mail accounts of employees of Idorsia Pharmaceuticals (including any of its subsidiaries, affiliates or related companies) are considered the property of Idorsia Pharmaceuticals and are not subject to payment of any form of introduction, placement or referral fees.