Lab Head Genomics

Location: 

Basel, BS, CH

 

 

About Idorsia Pharmaceuticals Ltd

Idorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients.

In order to achieve this, we will develop Idorsia into one of Europe’s leading biopharmaceutical companies, with a strong scientific core.

Headquartered in Switzerland - a European biotech hub - Idorsia is specialized in the discovery and development of small molecules, to transform the horizon of therapeutic options. Idorsia has a broad portfolio of innovative drugs in the pipeline, an experienced team, a fully-functional research center, and a strong balance sheet – the ideal constellation to bringing R&D efforts to business success.

Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 800 highly qualified specialists dedicated to realizing our ambitious targets.

 

We are looking for a motivated and experienced scientist that can champion the integration of genomics into our drug discovery and development projects. 

 

  • You will develop novel strategies to capitalize on the intrinsic value of (pharmaco) genomics and the overall translational biomarker strategy. 
  • You put great care in visualizing and explaining data to other functions, focussing on creating value for our projects. 
  • You will be able to bridge between computational, informatics disciplines, biology, and pharmacology.  
  • You will be responsible for applying the genomics expertise of the platform to a variety of projects in the fields of CV&Fibrosis, Immunology, Oncology and CNS.  
  • Your major responsibility will lie in the planning and execution of NGS experiments, as well as the integrated data analysis of complex datasets together with our data science team.  

 

The genomics platform is part of the Translational Biomarker Group that plays an important role in the different discovery phases as well as in early clinical development. 

 

Job Responsibilities

 

The Lab Head Genomics Platform will be further responsible for:

  • Explore, pilot, and implement established NGS protocols to support projects
  • Evaluate emerging NGS technologies and use industry networks to pragmatically select and pilot these technologies
  • Champion genomics in all its facets by active contributions to team and management meetings.
  • Provide leadership to the existing genomics platform and its lab members
  • Active representation of the biomarker group, particularly the genomics capabilities in selected R&D teams
  • Characterization of clinical translation through integrated analysis of animal models and clinical samples.
  • Drive the exploration of biomarkers and discovery of novel drug targets
  • Build the interface between the genomics platform and the Data Scientists in the Translational Biomarker group
  • Monitor and improve the effectiveness of Translational Biomarker strategy with other functions
  • Perform multivariate biomarker data analysis for several projects in close collaboration with functions in and outside the Translational Biomarker Group, putt experimental results into a biological context using internal and external knowledge databases
  • Collaborate with internal stakeholders to further develop capabilities for genomics data analysis with a focus on gene expression, exploring open-source solutions such as R/Bioconductor as well as commercial tools
  • Consult to Improve the standardized workflows: Data storage, data management, data retrieval with queries, data visualization and biological data interpretation based on the biological questions
  • Present and discuss scientific results in international meetings, be a representative of the Biomarker strategy of Idorsia towards an international expert audience

 

Candidate’s Requirements 

 

  • PhD in a life sciences relevant discipline and minimally 5 years postdoctoral experience in the field of gene expression and/or NGS analysis proven by a strong publication record.
  • Industry experience preferred. Experience in a pharmaceutical R&D environment and demonstrated experience in the clinical implementation of genomics, e.g., diagnostics or clinical trials would be an advantage
  • Line management experience demonstrated by the supervision of associates minimally at the MSc level. 
  • Experience with Illumina-based high throughput sequencing applications for the profiling of gene expression and targeted assays (including immune receptor sequencing) from different sample sources, including bioliquids and solid tissue, limited input and FFPE material
  • Extensive hands-on experience in current single cell sequencing technologies across all facets of library preparation and QC, including plate-based protocols (e.g., SmartSeq2 or -3) and/or high-throughput droplet-based systems (preferably 10X Genomics’ Chromium).
  • Demonstrated experience with multi-modal single cell protocols, including immune cell phenotyping using any combination of gene expression detection (scRNA), cell surface protein interrogation (e.g., CITE-seq) or chromatin accessibility profiling (scATAC-seq) 
  • Applied experience or extensive familiarity to guide best practices in preparing single cell suspensions, including enrichment of specific populations such as tumor-infiltrating or inflammatory lesion lymphocytes towards single cell sequencing or bulk transcriptomic methods starting from limited tissue material (e.g., patient biopsies or animal tissues)
  • A thorough understanding of strengths and limitations of current (single cell /) sequencing technologies to appropriately advise on the design of complex experiments in disease models that mutually leverage the groups’ multi-omics approaches (including sequencing, mass spectrometry, flow- and cytokine profiling)
  • Expert knowledge in genomics information resources and more advanced pathway / biological network and multivariate analyses
  • Familiar working within a UNIX environment. relevant experience in data analysis, use of R/Bioconductor and dissemination of results by reports in markdown or shiny apps
  • Experience in one or more of the therapeutic areas of interest to Idorsia would be an advantage
  • Proactive, forward-thinking and wish to be up to date with the technologies of this fast-evolving genomics field especially in NGS
  • Full professional proficiency in English
  • Demonstrated experience of working in multicultural and multidisciplinary environments
  • Result oriented, problem solver
  • Dynamic team player with excellent communication and networking skills, flexible mindset and scientifically curious

 

What Idorsia offers

 

  • Exciting opportunities for development and professional growth within our dynamic organization
  • A collaborative and solution-oriented environment where you can make a difference
  • An innovative and open culture in a truly multicultural environment
  • A competitive salary and generous social benefits

 

Work Location: Allschwil – Basel Area
Country: Switzerland
Business Area: Drug Discovery Biology Translational Biomarkers
Schedule: Fulltime
Job Type: Permanent
Job ID: 2532

 

 

If you are interested, please click on apply now.

Please be informed that if you are selected for this position, your employment will be subject to a pre-employment background screening process, of which you will be informed in greater detail in due course.

Idorsia operates a strictly controlled list of preferred recruitment partners. For those partners who have no valid, signed Master Service Agreement in place with Idorsia, please note that all unsolicited resumes, CVs, anonymous profiles, or any other candidate details submitted through our website or to personal e-mail accounts of employees of Idorsia Pharmaceuticals (including any of its subsidiaries, affiliates or related companies) are considered the property of Idorsia Pharmaceuticals and are not subject to payment of any form of introduction, placement or referral fees.