Temporary Scientific Associate, Metabolite Structure Analysis


Basel, BS, CH



About Idorsia Pharmaceuticals Ltd

Idorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients.

In order to achieve this, we will develop Idorsia into one of Europe’s leading biopharmaceutical companies, with a strong scientific core.

Headquartered in the Basel Area (Allschwil) in Switzerland - a European biotech hub - Idorsia is specialized in the discovery and development of small molecules, to transform the horizon of therapeutic options. Idorsia has a broad portfolio of innovative drugs in the pipeline, an experienced team, a fully-functional research center, and a strong balance sheet – the ideal constellation to bringing R&D efforts to business success.

Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 800 highly qualified specialists dedicated to realizing our ambitious targets.


In our Department for Preclinical Drug Metabolism and Pharmacokinetics (DMPK) we are seeking a


Temporary Scientific Associate in metabolite structure analysis

for approximately one year, who strives for the structural identification of drug metabolites and answer of related scientific questions arising from our early drug discovery and preclinical drug development projects.


Job Responsibilities


  • Structure identification and (semi-)quantification of drug metabolites using state-of-the-art LC-HRMS technology
  • Running biochemical assays in the field of drug metabolism (using recombinant enzymes, microsomes and hepatocytes)
  • Analysis of biological matrices (e.g. bile, feces, plasma, urine)
  • Planning, conducting, documenting, and reporting of experimental work
  • Implementation of new technologies and new assays
  • Maintenance of LC-MS equipment


Candidate’s Requirements 


  • Education in a scientific area related to organic analytical chemistry (e.g. technical diploma, bachelor or master level)
  • At least 2 years of practical experience in analysis of small organic molecules with HPLC-HRMS is mandatory
  • Profound experience in structure identification based on interpretation of MS/MS spectra is mandatory
  • Hands-on experience with Orbitrap-MS systems, Xcalibur software and CompoundDiscoverer software would be an advantage
  • Hands-on experience with in vitro assays in the field of drug metabolism would be an advantage
  • Hands-on experience in analysis of biological matrices would be an advantage
  • Experience in LC-MS-based quantification of small molecules would be an advantage
  • Experience in working with radioactive tracers (carbon 14, tritium) would be an advantage
  • Background in drug metabolism science would be an advantage
  • Very good team-working and communication skills with the capability to work in a project-driven environment
  • Efficient organization and good documentation of work
  • Good command of English; German or French would be an asset


What Idorsia offers


  • Exciting opportunities for development and professional growth within our dynamic organization
  • A collaborative and solution-oriented environment where you can make a difference
  • An innovative and open culture in a truly multicultural environment
  • A competitive salary and generous social benefits


Work Location: Allschwil – Basel Area
Country: Switzerland
Business Area: Preclinical Development - DM/PK
Schedule: Fulltime
Job Type: Temporary
Job ID: 2795



If you are interested, please click on apply now.

Please be informed that if you are selected for this position, your employment will be subject to a pre-employment background screening process, of which you will be informed in greater detail in due course.

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