Temporary Scientific Associate - in vitro / in vivo Neuropharmacology

Location: 

Basel, BS, CH

 

 

About Idorsia Pharmaceuticals Ltd

Idorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients.

In order to achieve this, we will develop Idorsia into one of Europe’s leading biopharmaceutical companies, with a strong scientific core.

Headquartered in the Basel Area (Allschwil) in Switzerland - a European biotech hub - Idorsia is specialized in the discovery and development of small molecules, to transform the horizon of therapeutic options. Idorsia has a broad portfolio of innovative drugs in the pipeline, an experienced team, a fully-functional research center, and a strong balance sheet – the ideal constellation to bringing R&D efforts to business success.

Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 800 highly qualified specialists dedicated to realizing our ambitious targets.

 

We are seeking a motivated Scientific Associate for a 9-month temporary position starting as soon as possible (replacement maternity leave).


Job Responsibilities

 

  • Prepare primary cultures of brain cells (microglia/astrocytes, neurons) 
  • Characterize in vitro cellular systems in terms of cell type markers and target expression, at the mRNA and protein levels (qRT-PCR, Western blot, Immunocytochemistry, FACS)
  • Perform viability and functional assays on brain primary cultures and cell lines (e.g. microglia migration, phagocytosis, cytokine release) to evaluate the potential of compounds 
  • Set up new in vitro models of neurodegeneration/neuroinflammation and related efficacy read-out depending on the project needs
  • Contribute to basic monitoring of mice and rats enrolled in pharmacological study (body weight measurement, disease scoring)
  • Sample biological fluids (CSF, blood) and tissues (brain, spinal cord, nerve, muscle) from rodents and perform biochemical analyses via different analytical methods (e.g., FACS, Western blot, Immunohistochemistry)
  • Responsible for the efficient planning, analysis and documentation of experiments in a multidisciplinary environment; writing of internal scientific reports
  • Communicate research findings internally and closely collaborating with other groups
  • Literature search for the setup of relevant experimental methods and optimization of existing protocols.
  • Supervise breeding of transgenic mouse/rat colonies

 

Candidate’s Requirements 

 

  • Bachelor or Master degree in Science (Biology/Pharmacology/Biochemistry), ideally with additional knowledge in Neuroscience; candidates holding a PhD will generally not be considered 
  • Extensive experience in isolation of cell populations from the CNS, cell culture, cellular assays, ideally in the field of neurodegeneration/neuroinflammation
  • Strong expertise in ex vivo analysis (gene expression, WB, ICC, FACS)
  • Recognized as an animal experimenter (LTK1 or equivalent)
  • Practical work experience in the field of neurodegeneration of  > 3 years, preferably in an industrial setting 
  • Hands-on experience in necropsy including brain (microdissection of brain regions), spinal cord, muscle sampling but also in animal dosing (oral gavage, subcutaneous, intraperitoneal, intramuscular, intravenous injections) would be an advantage. 
  • Ability to plan, methodically perform, carefully analyze, accurately document experiments and present results
  • Scientifically curious, willingness to learn new techniques and skills
  • Flexible and committed to work
  • Excellent knowledge of English (verbal and written)

 

What Idorsia offers

 

  • Exciting opportunities for development and professional growth within our dynamic organization
  • A collaborative and solution-oriented environment where you can make a difference
  • An innovative and open culture in a truly multicultural environment
  • A competitive salary and generous social benefits

 

Work Location: Allschwil
Country: Switzerland
Business Area: Drug Discovery PPD CNS
Schedule: Fulltime
Job Type: Temporary – 9 months
Job ID: 2608
 

 

 

If you are interested, please click on apply now.

Please be informed that if you are selected for this position, your employment will be subject to a pre-employment background screening process, of which you will be informed in greater detail in due course.

Idorsia operates a strictly controlled list of preferred recruitment partners. For those partners who have no valid, signed Master Service Agreement in place with Idorsia, please note that all unsolicited resumes, CVs, anonymous profiles, or any other candidate details submitted through our website or to personal e-mail accounts of employees of Idorsia Pharmaceuticals (including any of its subsidiaries, affiliates or related companies) are considered the property of Idorsia Pharmaceuticals and are not subject to payment of any form of introduction, placement or referral fees.